Homicide was produced for the Seven Network by the Melbourne-based Crawfords Productions, whose founder Hector Crawford has been a pivotal figure in Australian radio and television. With Homicide, Crawfords pioneered long production runs for serialized drama on modest budgets, and established the importance of the external production house as a source of local drama material for the commercial networks. Crawfords also pioneered outdoor location filming in Australia, which was an important part of Homicide's popularity with Australian audiences, who for the first time saw drama taking place in familiar urban locations. 

Homicide was an episodic crime drama, invariably involving a murder, with most episodes following closely a narrative structure in which the detective team investigates and, in the final segments, resolves the murder and arrests the perpetrators. The program was thus "realistic" in both narrative and visual representation. Still, the team of male detectives was detached from their social environment. They were always presented as part of a stable hierarchy; they were bound by thorough professionalism, and no consideration was given to their private lives. These factors place Homicide in an older tradition of TV police drama. Here dichotomies between law and crime, the police and the society in which they operate, their professional work and private lives, and the relationship of hierarchical authority to individual initiative remain stable and largely uncontested. Homicide can be seen as a program that defined the generic conventions of police drama in Australia, drawing upon the codes and conventions established in police dramas such as Dragnet in the United States and Z Cars in Britain, with more emphasis upon the narrative of crime-solving than on the development of character and the generation of conflict.

The peak years of Homicide were also the peak years of police drama on Australian TV, with it and other similar programs consistently rating highly with local, particularly male audiences. When production of Homicide ceased in 1975, the police drama had already declined in significance in programming schedules and popularity, giving way to the rise of the serial drama and, later, the miniseries.

The significance of Homicide to Australian television perhaps lies less in its textual innovations than in certain institutional factors. It demonstrated a capacity to present familiar environments and character types to Australian audiences on TV for the first time. It created an environment more conducive to policy measures that promoted local drama production and restricted imported material. And it exemplified the innovations in program production necessitated by the need to produce an on-going drama series. In many ways, the program demonstrates that Australia's international reputation as a country with a competitive advantage in low-budget strip programming has its origins in the production techniques developed at Crawfords in the 1960s.